"True believers may have the assurance of their salvation is divers ways shaken, diminished, and intermitted; as, by negligence in preserving of it, by falling into some special sin which woundeth the conscience and grieveth the Spirit; by some sudden or vehement temptation, by God's withdrawing the light of His countenance, and suffering even such as fear Him to walk in darkness and to have no light: yet are they never utterly destitue of that seed of God, and life of faith, that love of Christ and the brethrenn, that sincerity of heart, and conscience of duty, out of which ,by the operation of the Spirit, this assurance may, in due time, be revived; and by the which, in the meantime, they are supported from utter despair." (18:4)
When God seems distant we tend to blame Him. That's what the Israelites tried to do. However, Isaiah doesn't allow them that privilege. "The problem was not owing to God. He was still as able to help as ever. His hand is not shortened, His power is not lessened. God can reach as far as ever and with as strong a hand as ever. He was still as ready and willing to help as ever in answer to prayer."
God's ear is not so dull that it cannot hear. "If your prayers be not answered it is not because God is weary of hearing prayer but because we are weary of praying. It is not because His ears are heavy when we speak to Him, but because our ears are heavy when He speaks to us." (Matthew Henry)
Does God "seem" distant? Check yourself first. See if there is a sin within that is building up the wall of "seeming' separation. We are the ones who are prone to wander. God is an unmoving Rock. We are like shifting sand. He is a sure foundation. If you find that you have wandered, repent, believe, and watch and pray (Lk22:40,46).
God's hand is not short. His ear is not dull. His mercies are new every morning. Great is His faithfulness. In due time you will reap a harvest - a good harvest - if you will rest in and rely on Him. Don't grow weary in well-doing and trust that His grace is sufficient and that His timing is always perfect - no matter how things "seem".